ABSTRACT

Rev. Latinoamer. Quím. 38, (1), 12-20, (2010)

STUDY ON THE POSSIBLE PROTECTIVE EFFECT OF MELATONIN AND SILYMARIN AGAINST THE TOXIC
EFFECT OF FAVISM FACTOR "DIVICINE"

Mahmoud S. Arbid ^a, Sawsan S. Mahmoud ^a and Khaled M. M. Koriem ^b .

^a Pharmacology and ^b Medical Physiology Departments, Medical Research Division, National Research Centre, Dokki, Giza , Egypt

The present study was conducted to elucidate the possible protective effect of Melatonin and Silymarin in case of toxic effect of "Divicine" on albino rats. IP injection of DV alone resulted in 100% mortality and decrease in GSH concentration in RBCs. Administration of Mt and Sy with DV greatly reduced mortality and increased GSH concentration, while counteract the increase in liver and kidney functions found after divicine injection.

Key words: Divicine, GSH, melatonin, sylimarin, Favism, Rats.